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Analyzed the data: CCW. Due to narrow therapeutic window of cancer therapeutic agents and the development of resistance against these agents, there is a need to discover novel agents to treat breast cancer. The antitumor activities of thymoquinone TQa compound isolated from Nigella sativa oilwere investigated in breast carcinoma in vitro and in vivo.

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Overexpression of chemokine receptor type 4 CXCR4 has been found to be associated with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in patients with breast cancer. Therefore, new agents that can abrogate CXCR4 expression have potential against breast cancer metastasis. In this study, we examined the potential effect of thymoquinone TQderived from the seeds of Nigella sativaon the expression and regulation of CXCR4 in breast cancer cells.

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