Inhibitors used for breast carcinoma

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Over the course of a lifetime, one in eight women will be diagnosed with breast cancer. The following list of medications are in some way related to, or used in the treatment of this condition. For consumers: dosageinteractions .

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Aromatase, a cytochrome P enzyme that catalyzes the conversion of androgens to estrogens, is the major mechanism of estrogen synthesis in the post-menopausal woman. We review some of the recent scientific advances which shed light on the biologic significance, physiology, expression and regulation of aromatase in breast tissue. Inhibition of aromatase, the terminal step in estrogen biosynthesis, provides a way of treating hormone-dependent breast cancer in older patients.

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Hormones are substances that function as chemical messengers in the body. They affect the actions of cells and tissues at various locations in the body, often reaching their targets through the bloodstream. The hormones estrogen and progesterone are produced by the ovaries in premenopausal women and by some other tissues, including fat and skin, in both premenopausal and postmenopausal women and men.

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By Caroline Helwick July 10, Advertisement. The benefit was seen in both the first-line and second-line metastatic treatment settings. Exploratory statistical analyses within subset variables found no evidence of a treatment effect interaction, she reported.

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Selective serotonin reuptake inhibitors SSRIsthe first-line pharmacological treatment for depression, have been implicated in breast cancer development through increased prolactin levels and tamoxifen metabolism inhibition. Previous studies of breast cancer progression have focused on tamoxifen users, or have been limited by their small sample size and methodology. Therefore, we used UK population-based data to more robustly investigate the association between SSRI use and cancer-specific mortality.

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Describe the differences in study designs, clinical outcome, and safety data on aromatase inhibitors. Select the proper aromatase inhibitor based on a thorough understanding of the data that led to the specific indication for the drug. We examined published reports on the use of aromatase inhibitors in postmenopausal patients with hormone receptor-positive breast cancer. Current data indicate that aromatase inhibitors are equivalent or superior to tamoxifen as first-line therapy for metastatic breast cancer and as neoadjuvant treatment for primary breast cancer.

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Metastatic breast cancer also called stage IV or advanced breast cancer is not a specific type of breast cancer. It's the most advanced stage of breast cancer. Metastatic breast cancer is breast cancer that has spread beyond the breast and nearby lymph nodes to other organs in the body most often the bones, lungs, liver or brain.

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These agents prevent phosphorylation of the RB tumor suppressor, thereby invoking cancer cell cycle arrest in G1. In particular, we highlight that CDK4 and CDK6 govern much more than the cancer cell cycle, and that their optimal use in the clinic depends on a deeper understanding of the less well characterized effects of these enzymes. In breast cancer, much attention has been given to particular members of the cell cycle machinery — the D-type cyclins and their partner kinases, cyclin-dependent kinase 4 CDK4 and CDK6. These cancers almost always retain RB function at presentation, meaning that the principal pathway upon which these agents act is intact.

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