Gemcitabine metastatic breast cancer

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Impact factor 3. International Journal of Biological Sciences. International Journal of Medical Sciences.

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Heinemann med3. Gemcitabine is a pyrimidine antimetabolite which has shown activity in metastatic breast cancer both as a single agent, but also in various combination regimens. It is characterized by a unique mechanism of action which includes cytotoxic self-potentiation, masked DNA chain termination and potent inhibition of DNA repair.

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Gemcitabine is a chemotherapy drug used to treat breast cancer. Back to top. Gemcitabine is usually used in combination with another chemotherapy drug, either carboplatin or paclitaxel Taxol. Gemcitabine is given as a drip into a vein intravenously in the hand or arm, although there are other ways of giving it depending on factors such as how easy it is for chemotherapy staff to find suitable veins and your preferences.

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The aim of the study was to evaluate the efficacy and tolerability of single-agent gemcitabine in the maintenance treatment of histologically confirmed metastatic breast cancer cases. Patients in the maintenance therapy group received gemcitabine therapy until 6 cycles, disease progression or adverse effect intolerance. Within the control group, the patients were given best supportive care.

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Hu XC, et al. Lancet Oncol. Cisplatin plus gemcitabine demonstrated superior PFS outcomes compared with paclitaxel plus gemcitabine for women with metastatic triple-negative breast cancer, according to results of a randomized phase 3 study.

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Breast Cancer Recurrent or Metastatic. Clinical Trials: The National Comprehensive Cancer Network recommends cancer patient participation in clinical trials as the gold standard for treatment. Cancer therapy selection, dosing, administration, and the management of related adverse events can be a complex process that should be handled by an experienced healthcare team. Clinicians must choose and verify treatment options based on the individual patient; drug dose modifications and supportive care interventions should be administered accordingly.

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Gemcitabine is a chemotherapy drug classified as anti-cancer, antineoplastic or cytotoxic. It is also included in the group of drugs called anti-mebolites, which are meant to mimic the normal molecules in the body, but are slightly different in its structure in order to stop the cancer cells from properly working. It is currently being studied to treat other types of cancer.

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Ma, P. Steen, K. Rowland, R. Niedringhaus, T.

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