Her2 breast cancer

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HER2 status also helps your doctor determine how aggressive the cancer is and treatment options. There are many differences between HER2 positive and HER2 negative breast cancers, from the biology of the tumors, to risk factors, aggressiveness, and much more. Understanding these differences is critical for anyone who has learned they have a positive HER2 status.

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Notably, the Focused Update addresses uncommon clinical scenarios and improves clarity, particularly for infrequent HER2 test results that are of uncertain biologic or clinical significance. Updated findings of note include:. Stakeholders are encourage to review and download the following resources to help implement the Focused Update:.

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Approximately one in five women diagnosed with breast cancer will have HER2-positive disease. This is a particularly aggressive form of breast cancer which, if left untreated, is associated with faster disease progression and poorer chances of survival than HER2-negative disease. Globally, approximatelywomen are diagnosed with this type of breast cancer every year.

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Breast cancer is one of the most common cancers. Almost 25 percent of people newly diagnosed with cancer have breast cancer. One in 5 people with breast cancer have a type called HER2-positive.

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If you're struggling to find what you need, call our Support line on 7 days a week, 8am-8pm. HER2 human epidermal growth factor is a protein that can affect the growth of some breast cancer cells. If higher levels of it are found in a breast cancer, it is called HER2 positive breast cancer.

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The job of HER2 is to control a protein on the surface of cells that helps them grow. If the HER2 gene changes, it may help a tumour grow. Healthy cells have 2 copies of the HER2 gene.

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HER2 stands for human epidermal growth factor receptor 2. It is a gene that makes a protein found on the surface of all breast cells. It is involved in normal cell growth.

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Researchers hope the vaccine combined with trastuzumab can help prevent breast cancer recurrence. Treating breast cancer has long involved addressing two problems: the elimination of cancer cells from the tumor and potential disease recurrence. The key may be to harness the full capabilities of the body's immune system to do both jobs. On Mayo Clinic's campus in Florida, a team of researchers has a new anti-cancer vaccine in the works to help the body resist the return of human epidermal growth factor receptor 2 HER2 -positive breast cancer.

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Each healthy breast cell contains two copies of the HER2 gene. This gene is intended to help cells grow normally. If a breast cell has too many copies of the HER2 gene along with too much of the HER2 protein on the cell surface, the cell may grow out of control and become a tumor.

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As previously reported, the strategy does not worsen two-year overall survival but significantly shortens progression-free survival. The phase II trial randomly allocated patients to trastuzumab plus pertuzumab alone versus trastuzumab plus pertuzumab combined with chemotherapy until progression. After progression, both groups received T-DM1 as second line therapy. Progression-free survival after first line therapy was 8.

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